Vitamin B6 (pyridoxine) – “from all diseases”? Vitamin B6 for children: why it is useful and needed by the body, how to take it, daily dose, indications and contraindications Vitamins of the group in 6 ampoules instructions
P N013203/01, P N013203/02.Trade name of the drug:
Magne B 6 ® .Dosage form:
film-coated tablets, oral solution.Compound
Film-coated tablets
Tablet core:
active ingredients:
magnesium lactate dihydrate* - 470 mg;
pyridoxine hydrochloride - 5 mg;
Excipients: sucrose - 115.6 mg, heavy kaolin - 40.0 mg, acacia gum - 20.0 mg, carboxypolymethylene 934 - 10.0 mg, talc (magnesium hydrosilicate) - 42.7 mg, magnesium stearate - 6.7 mg.
Tablet shell: acacia gum - 3.615 mg, sucrose - 214.969 mg, titanium dioxide - 1.416 mg, talc (magnesium hydrosilicate) - traces, carnauba wax (powder) - traces.
* - equivalent to magnesium content (Mg++) 48 mg
Oral solution
Active ingredients:
magnesium lactate dihydrate** - 186 mg;
magnesium pidolate** - 936 mg;
pyridoxine hydrochloride - 10 mg;
Excipients: sodium disulfite - 15 mg, sodium saccharinate - 15 mg, cherry-caramel flavoring - 0.3 ml, purified water up to 10 ml.
** - equivalent to total magnesium content (Mg++) 100 mg
Description
oval biconvex film-coated tablets white, with a smooth shiny surface.
Oral solution:
transparent brown liquid with the smell of caramel.
Pharmacotherapeutic group
Magnesium preparation.
ATX code: A11JB.
Pharmacological properties
Pharmacodynamics
Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells and is involved in most metabolic reactions. In particular, it is involved in the regulation of the transmission of nerve impulses and muscle contraction. The body receives magnesium through food. A lack of magnesium in the body can occur when the diet is disrupted or when the need for magnesium increases (with increased physical and mental stress, stress, pregnancy, use of diuretics). Pyridoxine (vitamin B 6) is involved in many metabolic processes and in the regulation of nervous system metabolism. Vitamin B 6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum magnesium content:
Absorption of magnesium in the gastrointestinal tract is no more than 50% of the dose taken orally. 99% of magnesium in the body is found inside cells. Approximately 2/3 of intracellular magnesium is distributed in bone tissue, and the other 1/3 is in smooth and striated muscle tissue. Magnesium is excreted primarily in the urine. At least 1/3 of the dose of magnesium taken is excreted in the urine.
Indications for use
Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability, minor sleep disturbances; gastrointestinal cramps or rapid heartbeat; increased fatigue, pain and muscle spasms, tingling sensation.Contraindications
Carefully
With moderate renal failure, as there is a risk of developing hypermagnesemia.
Use during pregnancy and lactation
Pregnancy
Clinical experience with the use of the drug in a sufficient number of pregnant women has not revealed any adverse effects on the occurrence of fetal malformations or fetotoxic effects.
Magne B 6 ® can be used during pregnancy only if necessary, on the recommendation of a doctor.
Breastfeeding period
Magnesium passes into breast milk. The use of the drug should be avoided during lactation and breastfeeding.
Directions for use and doses
Before taking the drug, you should consult your doctor.Film-coated tablets
Adults are recommended to take 3-4 ampoules per day.
For children over 1 year old (body weight more than 10 kg), the daily dose is 10-30 mg magnesium/kg body weight (0.4 - 1.2 mmol magnesium/kg) or 1-4 ampoules.
The daily dose should be divided into 2-3 doses, taken with meals.
The tablets should be taken with a glass of water.
The solution from the ampoules is dissolved in? glasses of water.
Treatment should be stopped immediately after normalization of magnesium concentration in the blood.
Attention
Self-breaking ampoules with Magne B 6 ® do not require the use of a nail file. To open the ampoule, take it by the tip, having previously covered it with a piece of cloth, and break it off with a sharp movement, first from one pointed end and then from the other, having previously directed the end of the ampoule that opened first at an angle into a glass of water, so that the one being broken off by the second the tip of the ampoule was not above the glass. After breaking off the second tip of the ampoule, its contents will flow freely into the glass.
Side effect
Immune system disorders
Very rarely (< 0,01%): аллергические реакции, включая кожные реакции.
Gastrointestinal disorders
Unknown frequency (it is not possible to estimate the frequency of occurrence based on available data): diarrhea, abdominal pain, nausea, vomiting, flatulence.
Overdose
Symptoms
With normal kidney function, an overdose of magnesium when taken orally usually does not lead to toxic reactions. However, in case of renal failure, magnesium poisoning may develop.
Symptoms of overdose, the severity of which depends on the concentration of magnesium in the blood: decreased blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes in the electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.
Treatment
Rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.
Interaction with other drugs
Contraindicated combinations
Combinations to Consider
special instructions
Information for patients with diabetes mellitus: film-coated tablets contain sucrose as an excipient.In case of severe magnesium deficiency or malabsorption syndrome, treatment begins with intravenous administration of magnesium preparations.
In case of concomitant calcium deficiency, it is recommended to correct the magnesium deficiency before taking calcium supplements or dietary supplements containing calcium.
With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.
Ampoules contain sulfite, which can cause or intensify allergic reactions, including anaphylactic reactions, especially in patients at risk.
When pyridoxine is used in high doses (more than 200 mg per day) for a long time (over several months or in some cases years), sensory axonal neuropathy may develop, which is accompanied by symptoms such as numbness, impaired proprioceptive sensitivity, distal tremor limbs and gradually developing sensory ataxia (impaired coordination of movements). These disorders are usually reversible and disappear after stopping vitamin B 6 intake.
The drug in tablet form is intended only for adults and children over 6 years of age. For young children (over 1 year old), the drug is recommended in the form of an oral solution. Effect on ability to drive vehicles and engage in other potentially hazardous activities
Does not affect. There are no special recommendations.
Release form
Film-coated tablets10 tablets in a blister made of PVC/aluminum foil. 5 blisters along with instructions for use are placed in a cardboard box.
Oral solution
10 ml of the drug in dark glass ampoules (hydrolytic class III EF), sealed on both sides, with a break line and two marking rings on each side. 10 ampoules in a cardboard packaging insert along with instructions for use are placed in a cardboard box.
Best before date
Film-coated tablets: 2 years.Oral solution: 3 years.
The drug should not be used after the expiration date.
Storage conditions
Film-coated tablets: in a dry place, protected from light, at a temperature not exceeding 25? C.Oral solution: in a place protected from light at a temperature not exceeding 25? C.
Keep out of the reach of children.
Vacation conditions
Available without a prescription.Manufacturer
Film-coated tabletsSanofi Winthrop Industries. 82, Avenue Raspail, 94250 Gentilly - France.
Oral solution Sanofi Winthrop Industries. 82, Avenue Raspail, 94250 Gentilly, France. Cooperation Pharmaceutical Française. Place Lucien Auvers 77020 Melan, France. Consumer complaints should be sent to:
125009, Moscow, st. Tverskaya, 22.
1. Vitamin A, oil solution, capsules
Rp.: Retinoli acetatis oleosae pro injectionibus 100000 ME (1 ml)
D.t.d. 20 ampull. S. For intramuscular administration (1 ml daily).
Rp.: Tab. Retinoli acetatis 33,000 ME obductas
D.t.d. N. 20 S. For oral administration (1 tablet 2 times a day).
2. Vitamin B1,amp., tab.
Rp.: Sol. Thiamini chloridi 2.5% (5%) 1 ml
D.t.d. 10 ampull.
S. For intramuscular administration (1 ml daily).
Rp.: Tab. Thiamini chloride 0.005
S. For oral administration (1 tablet 3 times a day; for a weakened child in
age 3-8 years, patient with microsporia).
3. Vitamin B6, amp., tab.
Rp.: Tab. Pyridoxini 0.005 N 50
D.S. For oral administration for porphyrin photodermatoses (1 tablet 3 times
in a day; course of treatment 20-30 days)
Rp.: Sol. Pyridoxini 5% 1 ml
D.t.d. 10 ampull.
S. For intramuscular administration (1 ml 2 times a day).
4. Vitamin B12, amp., tab.
Rp.: Sol. Cyanocobalamini 0.01% 1 ml
D.t.d. 10 ampull.
S. For intramuscular administration for erythropoietic uroporphyria (Gunther's porphyria) and other skin diseases (1 ml daily for 10-12 days).
Rp.: Tab. Cyanocobalamini 0.00005 Ac. folici 0.0008
S. For oral administration (1 tablet 3 times a day).
5. VitaminE, oil solution, capsules, amp.
Rp.: Sol. Tocopheroli acetatis oleosae 5% (10; 30%) 10 ml (20; 25; 50 ml)
D.S. For oral administration during chills (on a piece of bread; 1 ml daily).
Rp.: Sol. Tocopheroli acetatis oleosae 50% 0.1 ml (0.2 ml).
D.t.d. N 10 in caps.
S. For oral administration (one capsule per day).
Rp.: Sol. Tocopheroli acetatis oleosae pro inject. 5% (10; 30%) 1 ml
D.t.d. 10 ampull.
S. For intramuscular administration (no 1 ml daily, two-step).
6. Folicacid, tab.
Rp.: Acidi folici 0.001 in tabul.
S. For oral administration for photodermatoses, psoriasis and other skin conditions
diseases (2 tablets 3 times a day).
7. Nicotinic acid, tab., amp,
Rp.: Sol. Acidi nicotinic 1% 1 ml
D.t.d. N. 10 in ampull.
S. For intravenous administration for pellagra and pellagroide (5 ml 1-2 times per
day for 2-3 weeks).
Rp.: Tab. Acidi nicotinic 0.05 N 50
D.S. For oral administration (2 tablets 3-4 times a day after meals for 15-
8. Tavegil, amp., tab, antihistamine
Rp.: Tab. Tavegili 0.001 D.t.d. N 20
S. For oral administration (1 tablet 2-3 times a day).
Rp.: Sol. Tavegili 2 ml (2 mg) in ampull. D.t.d. N 5
S. For intramuscular administration (1 ampoule 2 times a day, morning and evening).
9. Diphenhydramine, amp., tab. antihistamine
Rp.: Tab. Dimedroli 0.05 D.t.d. N 20
S. For oral administration (1 tablet 2-3 times a day; in a hospital setting)
Rp.: Sol Dimedroli 1% 1 ml in ampull. D.t.d. N 10
S. For intramuscular administration (1 ampoule - 1 ml 2 times a day).
11. Suprastin, tab. antihistamine
Rp.: Tab. Suprastini 0.025 N 20
D.S. For oral administration (1 tablet 2-3 times a day with meals).
13. Calcium chloride, amp.
Rp.: Sol. Calcii chloridi 10% 10 ml
D.t.d. 6 ampull.
S. For intravenous administration (5-10 ml daily; course of treatment 5-10
injections).
14. Calcium gluconate, amp., tab.
Rp.: Tab. Calcii gluconatis 0.5 N 20
D.S. For oral administration (1-2 tablets 3-4 times a day before meals).
Rp.: Sol. Calcii gluconatis 10% 10 ml
D.t.d. 10 ampull.
S. For intramuscular or intravenous administration (5-10 ml every other day or
in 2 days).
15. Sodium thiosulfate, amp.
Rр.: Sol. Sodium thiosulfatis 30% 5 ml
D.t.d. N. 6 in ampull.
S. 1 ampoule into a vein slowly
16. Activated carbon, tab.
Rp.: Carbonis activati 0.5
D.t.d. N.20 in tabul.
S. 2 tablets 3 times a day.
17. Prednisolone, amp. and tab. glucocorticosteroid
Rp.: Prednisoloni 0.005
D.t.d. N. 50 in tab.
S. 2 tablets each. 3 r. per day after meals.
Rp.: Sol.Prednisoloni hydrochloridi 3%-1 ml
D.t.d. N. 20 in amp.
S. Into a vein, 1-3 ml slowly.
Rp.: Dexamethasoni 0.0005
D.t.d. N. 20 in tab.
S. 1 tablet 3 times a day during or after meals.
19.Polcortoron glucorticosteroid (Triamcinolonum), tab.
Rp.: Triamcinoloni 0.004
D.t.d. N. 100 in tabul.
S. 1 tablet 3 times a day.
20. Rifampicin, caps.antibiotic
Rp.: Rifampicini 0.15
D.t.d.N.30 in caps. gel.
S. 1 caps. Once a day 1 hour before meals.
21. Tubazid (Isoniazidum), anti-tuberculosis tablet
Rp.: Isoniasidi 0.1
D.t.d.N.30 in tab.
S. 1 tablet 3 times a day at the beginning of treatment, then daily. one dose.
22. Diaphenylsulfone, tab.
antileprotic
Rp.: Diaphenylsulfoni 0.05
D.t.d. N. 50 in tabul.
S. 1 tablet 2 times a day.
23. Benzylpenicillin sodium salt. B-lactam
Rp.: Benzylpenicillini-natrii 1,000,000 units
S. Into the muscle every 5 hours. Before entering dissolve the dose in 5 ml of 0.25% novocaine solution.
24. Bicillin-1,3,5.B-lactam
Rp.: Вicillini-1 600,000 units
S. Into the muscle once a week. Before administration, dissolve in 5 ml of isotonic sodium chloride solution.
(if the bottle contains 1,200,000 units, then once every 2 weeks)
Rp.: Вicillini-3 600,000 units
S. Into the muscle once every 6 days. Before administration, dissolve in 5 ml of isotonic sodium chloride solution.
(if the bottle contains 300,000 units, then once every 3 days)
Rp.: Bicillini-5 1,500,000 units
S. Into the muscle once every 4 weeks. Before entering dissolve the dose in 5 ml of 0.25% novocaine solution.
25.Retarpen.Bicillin-1.B-lactam
Rp.: Retarpeni 2 400 000 ED
S. . Into the muscle once every 1 week. Before administration, dissolve in 5 ml of water for injection.
(prescribed differently depending on the form of syphilis)
26. Erythromycin, tab. macrolide
Rp.: Erythromycini 0.25
D.t.d. N. 20 in tabul.
S. 1 tablet 4 times a day.
27. Doxycycline hydrochloride.
tetracycline
Rp.: Doxycyclini hydrochloridi 0.1
What is Vitamin B6 for? This frequently asked question. Let's find out in this article. The term is the name of a group of three forms that mutually transform into each other, representing one bioorganic compound. Different forms of the same compound are called spatial conformations and are named differently. However, the common name is pyridoxine.
Instructions for use of vitamin B6 in ampoules are presented below.
Using vitamin B6 in the form of ampoules
In medical use, vitamin B6 in ampoules is used mainly in cases where its use in tablet form is impossible. This happens, for example, when the patient is unable to swallow, or his gastrointestinal tract. In these situations, the drug pyridoxine in the form of a solution is administered to a person intravenously or intramuscularly, and as a result, its absorption is in no way determined by the functioning and state of the gastrointestinal tract. The price of vitamin B6 in ampoules interests many.
To put it simply, it is an option that replaces pills with it, and it is used in the most severe cases. There is rarely a truly urgent need for injections of vitamin B6; most often they are used by doctors during hospital treatment of patients. Pyridoxine, administered intramuscularly or intravenously, acts on the body in the same way as if it enters a normally functioning digestive tract, which means that if it is possible to use it in tablet form, then injecting it is irrational. There are a lot of reviews about vitamin B6 in ampoules.
Need for home use
However, situations often arise when vitamin preparations need to be injected at home. In addition, pyridoxine in ampoules is often used not for its intended purpose, but also for cosmetic purposes, for example, for scalp and hair care. If we also take into account such a factor as the low price, then it becomes clear why they often experiment with it and add it to various homemade care products and masks.
In what cases is vitamin B6 in ampoules used?
Applicable as component complex therapy for serious diseases. In principle, all indications for the use of vitamin B6 can be divided into three large types:
When the patient is unable to swallow tablets containing pyridoxine, for example, with a severe mental disorder, in a faint state, with a categorical refusal to follow the doctor’s instructions, with severe vomiting and nausea, while using a ventilator.
Defects in the functioning of the gastrointestinal tract, when the vitamin, even if the patient has swallowed it, is not absorbed or is absorbed in an amount that is insufficient. Such disorders include degenerative transformations of the intestinal epithelium, malabsorption syndrome, the state of the gastrointestinal tract after extensive surgery (for example, after removal of part of the intestine or stomach), peptic ulcer.
The need for very large doses of the drug, which cannot be absorbed from the gastrointestinal tract at the required speed and must enter directly into the blood. A similar need sometimes arises in case of isoniazid poisoning, diabetes mellitus, hematopoietic defects and hemodialysis. This is confirmed by the instructions for use included with vitamin B6 in ampoules.
In the field of cosmetology
In the field of cosmetology, the use of vitamin B6 in the form of ampoules is most often noted for hair, since it has been noticed that when it is added to masks and shampoos, the hair becomes stronger and begins to grow faster, and the scalp becomes healthier. If this is the goal, then vitamin B6 should be used in ampoules, since making the corresponding remedy using tablets would be very difficult and, in principle, irrational.
Vitamin B6 preparations for injections
Vitamin B6 solution in injections is currently sold under a number of trade names. The most widely used among them are: “Pyridoxine”, “Vitamin B6”, “Pyridoxine hydrochloride”, “Pyridoxine-Vial” and “Pyridoxine-Bufus”. In fact, all of the above drugs have the same composition, but differ only in their names and manufacturing companies. In addition, vitamin B6 is often used in ampoules, mixed with other vitamins. These are mainly combinations with B1 and B12.
For self-injections, such drugs should be purchased only after consultation with a specialist.
Sometimes they ask whether it is possible to drink vitamin B6 in ampoules. It is possible, but absolutely useless, since during the digestive process the digestibility will decrease to 10%. Therefore, injections are much more effective.
special instructions
Probably the most important distinguishing feature injections using vitamin B6 - quite noticeable pain. That is why many pyridoxine preparations in the form of ampoules contain lidocaine, which has an analgesic effect when administered intramuscularly.
What foods contain vitamin B6? Animal products contain a lot of it: eggs, shrimp, oysters, salmon, tuna, ham, chicken, minced beef and lamb, liver, cottage cheese, cheese and other dairy products.
Pyridoxine is also present in plant products: in sprouted grains, potatoes, peas, cabbage, carrots, tomatoes, lentils, soybeans, leafy green vegetables, many cereals and cereals, yeast, nuts, seeds, berries and fruits. A large number of Vitamin B6 is found in bananas.
In medical practice, intravenous administration of the drug is most used, because in this case the vitamin in full enters directly into the blood. That is why during inpatient therapy, pyridoxine is most often administered by infusion at different rates.
Judging by the standard instructions, injections of the drug can also be carried out in gluteal muscle. To make one injection, it is enough to take a syringe with a volume of two milliliters (usually the ampoule contains exactly this amount of vitamin, and in large quantities the product must be administered intravenously). In this case, the indications for the use of vitamin B6 must be strictly observed.
Procedure
When performing an intramuscular injection, the following procedure must be followed:
the patient is placed on his stomach, he needs to completely relax the gluteal muscles;
prepare a cotton swab moistened with alcohol;
the tip of the ampoule is broken off, so it is better to wrap it in a napkin to avoid accidentally injuring your finger;
using a syringe, draw the solution from the ampoule;
squeeze out all the air from the syringe by turning it upward with the needle (the piston must be pressed until a drop of solution comes out of the needle, which means that only liquid remains in the syringe; if there is air in the syringe, then when injecting it into the muscle a hematoma may form;
the needle should be held between the middle and index fingers approximately one to two centimeters from the end;
turn the palm so that the tip of the needle is under it, and the syringe is above the hand;
give a slap to the place where the solution will be injected (most often this is the outer upper corner of a buttock); the needle must be inserted into the muscle two-thirds of its length;
the drug is administered by gradually pressing the piston;
the needle is removed and a swab moistened with alcohol is applied to the area where the solution was injected. Here's how to give vitamin B6 injections.
If during the injection the patient feels unbearable acute pain, then the needle must be removed immediately. Typically, such feelings arise when the needle touches a nerve node.
You should not crush or rub the place where the injection was given, since in this case the absorption of the drug will be disrupted and capillary injuries will form.
The injection into the thigh is done according to the same scheme, but the patient must stand on one leg, and the other, where the solution will be injected, must be slightly bent. In this case, the body weight will be transferred to the supporting leg, and the muscle into which the injection is given will relax. Typically, vitamin B6 is not injected into the thigh.
When the injection is done, you need to put a cap on the syringe needle, remove it and dispose of it. The syringe must not be reused because it is no longer sterile.
Contraindications
If you follow the instructions for using vitamin B6 in ampoules, then this product cannot be administered even in small quantities if there are contraindications such as:
Hypervitaminosis B6, when tingling is felt in the fingers (sometimes they seem to go numb);
Individual intolerance to the drug and the appearance of allergic reactions;
Symptoms of poisoning and overdose (this rarely happens);
The use of drugs that are incompatible with pyridoxine, for example, penicillamine and cuprimine, which completely deactivate pyridoxine; Vitamin B6 should also not be used when taking a number of anticonvulsants and anti-tuberculosis drugs, as it reduces the effectiveness of their effects;
Severe liver damage;
Peptic ulcer;
Ischemic heart disease.
The doctor may decide to use pyridoxine preparations even if there are any of the listed contraindications, but the patient must be under constant supervision of a specialist.
It is prohibited to use the product in ampoules on your own initiative if there are contraindications.
Vitamin B6 in ampoules: price
The drug is inexpensive - 30-40 rubles.
The cost of drugs with additional vitamins is as follows:
- “Kombilipen”, for five ampoules of which each with a volume of two milliliters you need to pay about two hundred rubles;
- “Vitagamma” - about one hundred rubles for the same amount;
- “Compligam B” - about two hundred and fifty rubles, the volume is the same.
Thank you
The site provides reference information for informational purposes only. Diagnosis and treatment of diseases must be carried out under the supervision of a specialist. All drugs have contraindications. Consultation with a specialist is required!
Magne B6 is a drug that replenishes the deficiency of magnesium and vitamin B 6 in the human body, regardless of the reasons that provoked it. The drug is used for the prevention and treatment of magnesium deficiency and related disorders, such as sleep disorders, nervous excitability, mental or physical fatigue, pain and muscle spasms, anxiety attacks with hyperventilation, as well as asthenia.Composition, release forms and varieties of Magne B6
![](https://i0.wp.com/tiensmed.ru/news/uimg/42/magneb6-ab3.jpg)
Magne B6 is available in two dosage forms:
- Tablets for oral administration;
- Oral solution.
The composition of tablets and solution of both varieties of Magne B6 as active ingredients includes the same substances - magnesium salt and vitamin B 6, the quantities of which are reflected in the table.
Active components of Magne B6 tablets (amount per tablet) | Active components of Magne B6 forte tablets (amount per tablet) | Active components of Magne B6 solution (amount per ampoule) |
Magnesium lactate dihydrate 470 mg, corresponding to 48 mg of pure magnesium | Magnesium citrate 618.43 mg, which corresponds to 100 mg of pure magnesium | Magnesium lactate dihydrate 186 mg and magnesium pidolate 936 mg, equivalent to 100 mg pure magnesium |
Vitamin B6 in the form of pyridoxine hydrochloride – 5 mg | Vitamin B6 in the form of pyridoxine hydrochloride – 10 mg |
Thus, as can be seen from the table, one tablet of Magne B6 forte contains the same amount of active substances as one full ampoule of solution (10 ml). And Magne B6 tablets contain two times less active substances compared to a full ampoule of solution (10 ml) and Magne B6 forte. This should be kept in mind when calculating dosages for taking the drug.
Auxiliary components of both varieties of Magne B6 are also reflected in the table.
Excipients of Magne B6 tablets | Excipients of Magne B6 forte tablets | Excipients of Magne B6 solution |
Titanium dioxide | Hypromellose | Sodium disulfite |
Carnauba wax | Titanium dioxide | Sodium saccharinate |
Acacia gum | Lactose | Cherry caramel flavor |
Kaolin | Macrogol | Purified water |
Carboxypolymethylene | Magnesium stearate | |
Magnesium stearate | Talc | |
Sucrose | ||
Talc |
Magne B6 and Magne B6 forte tablets have the same oval, biconvex shape and are painted in a shiny white color. Magne B6 is packaged in carton boxes 50 pieces each, and Magne B6 forte - 30 or 60 tablets.
Magne B6 oral solution is bottled in sealed ampoules of 10 ml. The package contains 10 ampoules. The solution is colored brown transparent and has a characteristic caramel smell.
Therapeutic effect
![](https://i0.wp.com/tiensmed.ru/news/uimg/32/magneb6-ab4.jpg)
Magnesium deficiency can develop due to the following reasons:
- Congenital pathology of metabolism, in which this element is poorly absorbed in the intestines from food;
- Insufficient intake of the element into the body, for example, due to malnutrition, starvation, alcoholism, parenteral nutrition;
- Malabsorption of magnesium in digestive tract for chronic diarrhea, gastrointestinal fistulas or hypoparathyroidism;
- Loss of large amounts of magnesium due to polyuria (urine excretion in a volume of more than 2 liters per day), taking diuretics, chronic pyelonephritis, renal tubular defects, primary hyperaldosteronism or the use of Cisplastin;
- Increased need for magnesium during pregnancy, stress, taking diuretics, as well as during high mental or physical stress.
Magne B6 - indications for use
Both varieties of Magne B6 have the same following indications for use:1. Identified and confirmed by laboratory test data, magnesium deficiency, in which a person has the following symptoms:
- Irritability;
- Sleep disorders;
- Spasms of the stomach and intestines;
- Heartbeat;
- Muscle spasms and pain;
- Tingling sensation in muscles and soft tissues.
Magne B6 - instructions for use
Magne B6 tablets
![](https://i1.wp.com/tiensmed.ru/news/uimg/e6/magneb6-ab5.jpg)
The tablets must be taken with meals, swallowed whole, without biting, chewing or crushing in any other way, and with a glass of still water.
The dosage of Magne B6 is determined by the person’s age:
- Adults and adolescents over 12 years of age – take 6–8 tablets per day (2 tablets 3 times a day or 4 tablets 2 times a day);
- Children over 6 years old with a body weight of more than 20 kg - take 4-6 tablets per day (2 tablets 2-3 times a day).
Dosages of Magne B6 forte are determined by the person’s age:
- Adults and adolescents over 12 years of age - take 3-4 tablets per day (1 tablet 3 times a day or 2 tablets 2 times a day);
- Children 6 - 12 years old - take 2 - 4 tablets per day (1 tablet 2-3 times a day or 2 tablets 2 times a day).
The average duration of treatment is 3 – 4 weeks. If the drug is taken to eliminate magnesium deficiency, then the course of treatment is completed when, according to the results of laboratory tests, the concentration of this element in the blood is normal. If the drug is taken for prophylactic purposes, the course of treatment is 2–4 weeks.
special instructions
In case of moderate and mild renal failure, the drug should be used with caution, constantly monitoring the level of magnesium in the blood, since due to the low rate of excretion of the drug by the kidneys, there is a risk of developing hypermagnesemia (increased concentration of magnesium in the blood). If renal failure is severe and CC (according to the Rehberg test) is less than 30 ml/min, then Magne B6 is contraindicated for use in any form (both tablets and solution).Children aged 1 – 6 years should be given Magne B6 only in solution form. Children over 6 years of age who weigh more than 20 kg can be given Magne B6 in tablet form (including Magne B6 forte). But if a child over 6 years old has a body weight of less than 20 kg, then he cannot be given the drug in tablets; in this case, a solution should be used.
If a person has a severe degree of magnesium deficiency, then before taking Magne B6, several intravenous injections of appropriate drugs should be made.
If a person has a combined deficiency of calcium and magnesium, then it is first recommended to take a course of Magne B6 to eliminate the deficiency of magnesium, and only after that begin to take various dietary supplements and medications to normalize calcium levels in the body. This recommendation is due to the fact that in conditions of magnesium deficiency, calcium entering the body is very poorly absorbed.
If a person often drinks alcoholic beverages, laxatives, or constantly endures heavy physical or mental stress, then he can take Magne B6 to prevent magnesium deficiency in the body without any special tests. In this case, the usual preventive course is 2–3 weeks, and it can be repeated every 2–3 months.
Magne B6 solution contains sulfite as excipients, which can increase the manifestations of allergies, which must be kept in mind and taken into account by people prone to hypersensitivity reactions.
When taking the drug in high dosages (more than 20 tablets of Magne B6 forte and more than 40 tablets or 40 ampoules of Magne B6) for a long time, there is a risk of developing axonal neuropathy, which is manifested by numbness, impaired pain sensation, tremor of the arms and legs and gradually increasing coordination disorder movements. This disorder is reversible and disappears completely after discontinuation of the drug.
If, despite taking Magne B6, the symptoms of magnesium deficiency (excitability, muscle cramps, irritability, insomnia, fatigue) do not decrease or go away, then you should stop using the drug and consult a doctor to clarify the diagnosis.
Impact on the ability to operate machinery
Neither tablets nor solution of Magne B6 affect a person’s ability to control mechanisms, therefore, while taking any form of the drug, you can exercise various types activities that require high reaction speed and concentration.Overdose
An overdose of Magne B6 is possible, but, as a rule, this occurs against the background of renal failure. In people who do not suffer from kidney disease, an overdose of Magne B6 is usually not observed.Symptoms of an overdose of Magne B are the following:
- Reduced blood pressure;
- Nausea;
- CNS depression;
- Reduced severity of reflexes;
- Changes on the ECG;
- Respiratory depression up to paralysis;
- Anuria (lack of urine).
Interaction with other drugs
Magne B6 reduces the severity of the therapeutic effect of Levodopa. Therefore, it is recommended to avoid the combined use of Levodopa with Magne B6, however, if there is an urgent need to take these drugs, then peripheral dopa decarboxylase inhibitors (Benserazide, etc.) should also be prescribed. In other words, the combination of Levodopa and Magne B6 is possible only with the additional use of a third drug from the group of dopa decarboxylase inhibitors.Calcium and phosphate salts impair the absorption of magnesium in the intestine, so they are not recommended for use simultaneously with Magne B6.
Magne B6 reduces the absorption of tetracyclines (Tetracycline, Oxytetracycline, Chlortetracycline, Doxycycline) in the intestine, so an interval of at least 2 to 3 hours should be maintained between taking these drugs. That is, Magne B6 should be taken either 2 - 3 hours before or 2 - 3 hours after taking a tetracycline antibiotic.
Magne B6 weakens the effects of thrombolytic agents (Streptokinase, Alteplase, etc.) and anticoagulants (Warfarin, Thrombostop, Phenilin, etc.), and impairs the absorption of iron preparations (for example, Fenyuls, Ferrum Lek, Sorbifer Durules, etc. .).
Magne B6 during pregnancy
Magne B6 is approved for use during pregnancy, since long-term observations and experimental studies have not revealed any negative impacts of this drug for the fetus and mother.Magne B6 is widely prescribed to pregnant women, since its benefits are obvious in almost all cases. Thus, magnesium, which is part of the drug, helps reduce excitation in the central nervous system, due to which the woman becomes calmer, nervousness, moodiness, mood swings, etc. disappear. Of course, the calmness of the expectant mother has a positive effect on the child.
Vitamin B6, also included in the drug, is necessary for normal growth and development of the nervous system and heart of the fetus. Against the background of vitamin B6 deficiency, the fetus may develop malformations of the heart, its valve apparatus or the central nervous system. Magne B6 prevents such pregnancy complications.
Thus, it is obvious that Magne B6 improves not only the physical condition of a pregnant woman and eliminates uterine hypertonicity, but also has a positive effect on the emotional background and relieves unnecessary stress.
However, Magne B6 is prescribed to almost all pregnant women in fairly long courses, even if the woman does not have a threat of miscarriage, hypertension, tics, etc. This practice is due to the fact that during pregnancy the consumption and need for magnesium doubles, and quite often a woman does not receive the required amount of the microelement from food or vitamins, as a result of which she develops certain symptoms of microelement deficiency. Therefore, doctors consider the prophylactic prescription of Magne B6 to be justified in order to prevent deficiency of magnesium and vitamin B6.
remember, that Symptoms of magnesium deficiency are:
- Spasms, cramps, muscle tics, nagging pain in the lower back or lower abdomen;
- Dizziness, headaches, sleep disorders, irritability;
- Arrhythmia, increased or decreased arterial pressure, palpitations, heart pain;
- Nausea, vomiting, alternating constipation with diarrhea, cramps and abdominal pain;
- Tendency to edema, low body temperature, constant chilliness.
During pregnancy, it is optimal to take 2 tablets of Magne B6 or 1 tablet of Magne B6 forte 3 times a day with meals.
Magne B6 for children
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Magne B6 is available in two dosage forms - tablets and oral solution. Tablets can only be given to children over 6 years old, provided that their body weight has reached 20 kg or more.
The dosage of Magne B6 for children is determined by their age and body weight:
- Children aged 1 – 6 years with a body weight of 10 – 20 kg– take 1 – 4 ampoules per day, having previously calculated the exact dosage based on body weight, based on the ratio of 10 – 30 mg of magnesium per 1 kg of weight per day;
- Children aged 6 – 12 years, weighing more than 20 kg– take 1 – 3 ampoules per day (1/3 – 1 ampoule 3 times a day) or 4 – 6 tablets per day (2 tablets 2 – 3 times a day);
- Teenagers over 12 years old– take 2 – 4 ampoules per day (1 ampoule 2-3 times a day or 2 ampoules 2 times a day) or 6 – 8 tablets per day (2 tablets 3 times a day or 4 tablets 2 times a day).
For children 1–6 years old, it is recommended to calculate the dosage individually based on body weight. For example, a child’s weight is 15 kg, which means he can be given a solution in a dosage of 10 * 15 = 150 mg, or 30 * 15 = 450 mg per day (calculation is based on the amount of magnesium). Since one full ampoule contains 100 mg of magnesium, 150 mg and 450 mg correspond to 1.5 or 4.5 ampoules. When the calculation results in an incomplete number of ampoules, it is rounded to whole numbers. That is, in our example, 1.5 ampoules are rounded to 2, and 4.5 - to 4, since the maximum permissible dosage for a child 1 - 6 years old is 4 ampoules.
Magne B6 forte can be given to children over 6 years old, provided that their body weight is more than 20 kg. The dosage of Magne B6 forte for children of different ages is as follows:
- Teenagers over 12 years old– take 3 – 4 tablets per day (1 tablet 3 times a day or 2 tablets 2 times a day);
- Children 6 – 12 years old– take 2 – 4 tablets per day (1 tablet 2-3 times a day or 2 tablets 2 times a day).
The course of use of Magne B6 for children without confirmed magnesium deficiency is 2–3 weeks. For children with identified and laboratory-confirmed magnesium deficiency, the drug is given until the level of the mineral in the blood rises to normal values.
Analogues
Magne B6 has two types of analogues - these are synonyms and, in fact, analogues. Synonyms include medications, which contain the same active substances as Magne B6. Analogues include drugs that have a similar spectrum of therapeutic action, but contain other active substances.On the Russian pharmaceutical market Magne B6 has only three synonymous drugs:
- Magnelis B6;
- Magwit;
- Magnesium plus B6.
The following drugs are analogues of Magne B6:
- Additiva magnesium effervescent tablets;
- Vitrum Mag chewable tablets;
- Magne Positive tablets;
- Magne Express granules for resorption;
- Magnerot tablets;
- Magnesium-Diasporal 300 granules for the preparation of solution for oral administration;
- Magnesium plus tablets.
Cheap analogues of Magne B6
The following drugs are cheaper synonyms than Magne B6:- Magnelis B6 – 250 – 370 rubles for 90 tablets;
- Magnesium plus B6 – 320 – 400 rubles for 50 tablets.
The only cheaper analogue of Magne B6 is Vitrum Mag - 270 - 330 rubles for 30 tablets.