Diphenhydramine indications for injection. What are diphenhydramine injections for? Diphenhydramine: what it helps with, instructions for use, analogues. Basic physical and chemical properties. Description of the drug: release form, cost and composition

Content

To relieve allergy attacks and swelling, Diphenhydramine is used in tablets or injections. This drug causes drowsiness and therefore has restrictions on its use. Its use is common in complex therapy with other medications, which together give a successful treatment result. Read the instructions for use of the medication.

What is Diphenhydramine

According to the accepted medical classification, Diphenhydramine belongs to histamine receptor blockers and antiallergic drugs. The active substance of the composition is diphenhydramine hydrochloride, which acts on the central nervous system, inhibiting histamine and cholinergic structures with brain receptors. Due to this effect, the spasm of smooth muscles is relieved, and a person’s condition with allergies is alleviated.

Composition and release form

The main forms of release of the drug are injection solution and tablets. The first can be taken orally or dropped into the eyes. In addition, rectal suppositories are produced based on the active ingredient. The composition and description of the drugs are indicated in the table:

		Pills
Description	Transparent colorless	White flat-cylindrical with chamfer and notch
Diphenhydramine concentration, mg		30, 50 or 100 per 1 piece / 20 for children
	Purified water for injections	Stearic acid, potato starch, colloidal silicon dioxide, lactose
Package	Ampoules 1 ml, 10 pcs. in a pack with instructions for use	Blisters or strips of 6 or 10 pcs., packs of one blister each

Physico-chemical properties of Diphenhydramine

The drug belongs to the blockers of histamine receptors in the brain. Due to this, Diphenhydramine relieves spasm of smooth muscles, reduces capillary permeability, and weakens the intensity of allergic reactions. The active substance in the local anesthetic drug has antiemetic activity, a sedative effect, and a hypnotic effect.

The drug causes local anesthesia, which manifests itself in a short-term feeling of numbness of the oral mucosa, and has an antispasmodic effect. Diphenhydramine is more effective for bronchospasm caused by histamine liberators (morphine), less effective for the allergic type. The drug is ineffective against bronchial asthma and can be combined with bronchodilators (Theophylline, Ephedrine).

Diphenhydramine antagonizes the effect of histamine, increases arterial pressure. In patients with a deficiency of circulating blood volume, parenteral administration of Diphenhydramine may cause a decrease in pressure and increase hypotension due to its ganglion-blocking effect. In case of local brain damage and epilepsy, the drug can activate epileptic discharges and provoke an attack of epilepsy.

The drug begins to act in a few minutes, its effect lasts up to 12 hours. Diphenhydramine is 98% bound to plasma proteins, metabolized in the liver, lungs and kidneys, excreted by the kidneys, and into breast milk in the form of conjugate metabolites with glucuronic acid. The active substance of the composition penetrates the blood-brain barrier, trace amounts are found in breast milk.

Indications for use

The instructions for use of Diphenhydramine solution and tablets indicate the following indications for use:

• complex therapy of anaphylactic and anaphylactoid reactions;
• Quincke's edema, premedication (preparation for intervention);
• serum sickness;
• acute allergic conditions;
• treatment of urticaria, hay fever, angioedema of tissues;
• allergic conjunctivitis;
• sleep disturbances, chorea, vomiting of pregnancy;
• seasickness, air sickness, Meniere's syndrome;
• drug allergies, treatment of poisoning;
• acute iridocyclitis;
• radiation sickness;
• allergic eye diseases, conjunctivitis.

Directions for use and dosage

Depending on the form of release of Diphenhydramine, the method of its use and dosage regimen differ. So, the tablets are taken orally, have pediatric and adult dosages, the course of administration depends on the type of disease and the severity of its course. The solution has a wider range of applications - it is administered intramuscularly, intravenously, used in the form of drops and orally.

In ampoules

Diphenhydramine injections are given intramuscularly (50-250 mg) or intravenously (20-50 mg), for adults and children over 14 years of age, the dosage is 1-5 ml of solution 1-3 times a day, a maximum of 200 mg can be administered per day. Children aged 7-12 months are prescribed 0.3-0.5 ml, 1-3 years old - 0.5-1 ml, 4-6 years old - 1-1.5 ml, 7-14 years old - 1.5-3 ml every 6-8 hours. The exact dosage is determined by the doctor; self-administration of injections is not advisable.

In tablets

For adults, Diphenhydramine tablets are taken in an amount of 30-50 mg 1-3 times a day for a course of 10-15 days. A single dose for children under one year old is 2-5 mg, a child 2-5 years old should take 5-15 mg, 6-12 years old – 15-30 mg. Diphenhydramine as a sleeping pill is taken 50 mg before bedtime. The dosage prescribed by the doctor should not be exceeded due to the increased likelihood of negative reactions. The tablets are washed down with water and taken regardless of meals.

Candles

Suppositories are not produced under the name “Diphenhydrol”, but there are suppositories for rectal use containing analgin and diphenhydramine, for example, Analdim. They are used as an anesthetic after a cleansing enema and are injected into the rectum twice a day. Children 1-4 years old are prescribed one suppository, adults - 1-3 suppositories. The younger the child, the lower the concentration of active substances should be used. The course of treatment lasts 1-4 days.

Drops

For use in ophthalmology or allergology, Diphenhydramine drops are prescribed. To do this, 0.2-0.5% in a 2% solution of boric acid is instilled 1-2 drops 3-5 times a day into the conjunctival sac to relieve allergic reactions. The solution can also be administered intranasally to eliminate the symptoms of allergic rhinitis and sinusitis - 0.05 ml of the product into each nostril several times a day. The course of treatment is determined by the attending physician, who also prescribes the exact dosage of the medication.

special instructions

When studying the rules for using Diphenhydramine with antihistamine activity, you should pay attention to the special instructions in the instructions:

• during the treatment period, refrain from driving vehicles and dangerous machinery, since the drug causes a hypnotic effect, reduces the speed of psychomotor reactions and concentration;
• during therapy, avoid prolonged exposure to the sun due to the appearance of photosensitivity;
• the use of the drug as an antiemetic effect may make it difficult to diagnose appendicitis and recognize symptoms of overdose with other drugs.

Diphenhydramine during pregnancy

Doctors prescribe the drug with caution during pregnancy and lactation, since diphenhydramine can cause Negative consequences for the development of the child. Before taking it, the doctor must evaluate the benefit to the mother over the risk to the fetus, and if it is higher, prescribe the medication. During breastfeeding, Diphenhydramine passes into breast milk and may cause sedation in newborns or increased excitability. During lactation, taking the medication is contraindicated.

Diphenhydramine for children

Diphenhydramine should not be used for children without a doctor’s instructions and consideration of each case individually, determining the severity of the disease and indications for use. The use of solution for parenteral administration and injections is contraindicated under the age of seven months, tablets for oral administration - up to six years. Follow the dosage for your child exactly to avoid the risk of negative side effects. side effects and overexcitement.

Alcohol compatibility

According to research, the medication enhances the inhibitory effect of ethanol on the central nervous system, so you should avoid drinking alcohol and alcohol-containing drinks or medications during drug therapy. The combination of the drug with alcohol also has a negative effect on the liver, causing a risk of drug overdose and poisoning with alcohol metabolites.

Drug interactions

Before prescribing Diphenhydramine in combination therapy with other medications, you should study drug interactions drug:

• it enhances the effect of medications that have a depressant effect on the nervous system;
• monoamine oxidase inhibitors increase the anticholinergic activity of diphenhydramine;
• psychostimulants cause antagonistic interactions;
• it enhances the anticholinergic effects of drugs with m-anticholinergic action;
• you cannot combine the drug with products containing diphenylhydramine hydrochloride, even for local use (gels, creams, ointments), due to the possibility of overdose;
• tricyclic antidepressants can lead to increased intraocular pressure in glaucoma and enhance the anticholinergic effect of the drug.

Side effects

During the use of the drug, the systems and organs of the human body may develop such side effects as:

• drowsiness, weakness, lack of coordination of movements;
• tremor, dizziness, irritability, euphoria;
• agitation, insomnia, dry mucous membranes of the mouth and nose;
• anemia, decreased blood pressure, tachycardia;
• difficulty urinating, urticaria;
• allergic reactions, photosensitivity;
• skin rash, itching.

Overdose

Signs of exceeding the dose of Diphenhydramine are depression in adults or overexcitation in children. Depression may begin, the pupils dilate, the mouth becomes dry, and the person suffers from nausea and vomiting. There is no specific antidote, but Physostigmine can be prescribed if anticholinergic symptoms increase. The patient's stomach is washed and blood pressure is monitored. Adrenaline and analeptics should not be used in case of poisoning; oxygen should be provided and plasma-substituting fluids should be administered intravenously.

Contraindications

The drug is prescribed with caution for bronchial asthma, pregnancy, hyperthyroidism, increased intraocular pressure, and in old age. Contraindications for taking the medication are:

• lactation;
• increased sensitivity to components;
• angle-closure glaucoma;
• pheochromocytoma;
• prostatic hyperplasia;
• peptic ulcer of the stomach or duodenum, stenosis;
• epilepsy;
• childhood up to 7 months for solution, up to 6 years for tablets;
• bladder neck stenosis;
• use as a local anesthetic - due to the risk of developing local necrosis.

Terms of sale and storage

The medication is available by prescription and is stored away from children in a dark place at a temperature not exceeding 30 degrees for five years.

Analogues

There are several names of drug analogues with the same active substance. Also on sale are substitute drugs with other components, but with the same effect on the body. Popular medicines:

• Diphenhydramine chloride;
• Diphenhydramine;
• Allergan;
• Diphenhydramine;
• Restamin;
• Alledril;
• Diabenil.

Price

You can buy the medicine with a prescription in pharmacies or through online stores. The cost of the medicine depends on the type (tablets/solution), trade markup and concentration of the active substance. Prices for drugs in Moscow pharmacies are shown in the table.

Diphenhydramine (international nonproprietary name - diphenhydramine) is the “old man” of the antihistamine “workshop”, a representative of the first generation of this class of drugs. Has an impressive set pharmacological effects: in addition to, in fact, antihistamine (antiallergic), it is a sleeping pill, local anesthetic, anticholinergic, muscle relaxant, sedative, antiemetic.

The mechanism of action of diphenhydramine is associated mainly with its ability to inactivate H1 histamine receptors, thereby neutralizing the undesirable effects of the mediator of allergy and inflammation histamine. True, the disadvantage of diphenhydramine, as well as all first-generation antihistamines, is the reversible nature of the connection with H1 receptors, which requires more frequent use in fairly high doses. Removing histamine from the chain of biochemical interactions reduces the severity or completely eliminates smooth muscle spasms provoked by histamine, reduces the permeability of capillary walls, reduces tissue swelling, eliminates itching and prevents the flow of blood to the epicenter of the allergic reaction. Competition with histamine in diphenhydramine manifests itself mostly in relation to local vascular reactions (allergy, inflammation), and does not affect the systemic action of this mediator. Diphenhydramine has a local analgesic effect (which can be observed when taken orally by the example of numbness of the mucous membranes oral cavity), reduces the sensitivity of cholinergic receptors in the autonomic nerve ganglia (lowers blood pressure), has an antispasmodic effect.

Interacts with H3 histamine receptors in the brain, blocking them active centers. Reduces the activity of central cholinergic structures, thereby potentiating atropine-like reactions - dry mouth and nasopharynx, decreased diuresis, difficulty defecating, increased heart rate, visual impairment. This may help with rhinitis, but on the other hand - not the best option for bronchial asthma (as it contributes to airway obstruction), glaucoma and prostatic hyperplasia. The sedative and hypnotic effect of diphenhydramine becomes more pronounced with subsequent repeated doses of the drug. When administered intravenously in patients with low circulating blood volume, it may aggravate hypotension. Inhibits the cough reflex by directly interacting with the cough center of the medulla oblongata. When taken orally, it is quickly and well absorbed, reaching maximum concentrations in the blood within a time range of 1 to 4 hours from the moment of administration. The total duration of action of the drug is 4-6 hours. The sedative (calming) effect is determined by the fat solubility of diphenhydramine. Thus, it passes well through the blood-brain barrier and interacts with H1 receptors in the brain. Intensifies under the influence of alcohol and psychotropic substances.

Diphenhydramine is available in tablets and solution for injection. The dose and dosage regimen must be agreed with your doctor. Because The drug has a photosensitizing effect; you should avoid exposure to direct sunlight.

Pharmacology

Histamine H1 receptor blocker. It has antiallergic activity, has local anesthetic, antispasmodic and moderate ganglion-blocking effects. When taken orally, it causes a sedative and hypnotic effect, has a moderate antiemetic effect, and also has central anticholinergic activity.

When applied externally, it has an antiallergic effect.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal tract. Bioavailability is 50%. Cmax is reached after 20-40 minutes (the highest concentration is determined in the lungs, spleen, kidneys, liver, brain and muscles). Plasma protein binding – 98-99%. Penetrates through the BBB. Metabolized mainly in the liver, partially in the lungs and kidneys. T1/2 - 4-10 hours. During the day, it is completely excreted by the kidneys in the form of metabolites conjugated with glucuronic acid. Significant amounts are excreted in milk and may cause sedation in infants (a paradoxical reaction characterized by excessive excitability may occur).

Release form

10 pieces. - contour cell packaging (2) - cardboard packs.
10 pieces. - contour cell packaging (3) - cardboard packs.
10 pieces. - contour cell packaging (5) - cardboard packs.
10 pieces. - cellless contour packages.

Dosage

Adults orally - 30-50 mg 1-3 times a day. The course of treatment is 10-15 days. As sleeping pills- 50 mg before bedtime. IM - in doses of 50-250 mg; IV drip - 20-50 mg.

When taken orally, single doses for children under 1 year of age are 2-5 mg; from 2 to 5 years - 5-15 mg; from 6 to 12 years - 15-30 mg.

Apply externally 1-2 times/day.

Interaction

When used simultaneously, it enhances the effect of ethanol and drugs that depress the central nervous system.

When used concomitantly, MAO inhibitors enhance the anticholinergic activity of diphenhydramine.

Antagonistic interactions are observed when co-administered with psychostimulants.

Reduces the effectiveness of apomorphine as an emetic in the treatment of poisoning. Enhances the anticholinergic effects of drugs with anticholinergic activity.

Side effects

Possible: short-term numbness of the oral mucosa, drowsiness, general weakness, decreased speed of psychomotor reaction; Children may experience a paradoxical development of insomnia, irritability and euphoria.

Rarely: dizziness, headache, dry mouth, nausea, photosensitivity, accommodation paresis, incoordination, tremor.

Indications

Allergic reactions (urticaria, hay fever, angioedema), allergic conjunctivitis, vasomotor rhinitis, hemorrhagic vasculitis, serum sickness, pruritic dermatoses, sleep disorders (monotherapy or in combination with sleeping pills), chorea, sea and air sickness, vomiting of pregnancy, Meniere's syndrome , premedication.

Contraindications

Angle-closure glaucoma, prostatic hypertrophy, stenosing gastric and duodenal ulcers, bladder neck stenosis, bronchial asthma, epilepsy, hypersensitivity to diphenhydramine.

Features of application

Use during pregnancy and breastfeeding

During pregnancy and lactation (breastfeeding), diphenhydramine is used with caution, according to strict indications, in cases where the expected therapeutic effect for the mother outweighs the potential risk for the fetus or infant.

special instructions

Diphenhydramine should be used with caution during pregnancy and lactation.

During the treatment period, you should not be exposed to sunlight, and you should avoid drinking alcohol.

Impact on the ability to drive vehicles and operate machinery

Use with caution in patients engaged in potentially hazardous activities that require increased attention and rapid psychomotor reactions.

Each drug has specific indications for use. Often, drugs are used by patients without medical intervention. Often such cases end in complications and the addition of additional unpleasant symptoms. This is why it is so important to consult a doctor for therapy and receive individual recommendations.

Today's article will introduce you to a drug called Diphenhydramine. Find out what it helps with and in what situations it is necessary to use it. It is also worth mentioning the compatibility of this medicine with other drugs.

Description of the drug: release form, cost and composition

The drug "Diphenhydramine" is produced in different forms. At the pharmacy you can buy tablets and injection solution. Both versions of the drug are sold only as prescribed by a doctor. To buy the drug, you must have a prescription signed and stamped by a doctor. The drug "Diphenhydramine" has a fairly affordable price. Tablets of 10 pieces cost about 20 rubles. A package of injections can be purchased for 30 rubles.

The medicine contains the active ingredient diphenhydramine. One injection ampoule contains 1 milliliter of solution, which contains 0.01 grams of the main component. The tablet contains 0.05 grams of this substance. So, you already know in what form and composition Diphenhydramine is produced. Its price also became known. Remember that before using the drug you must read the instructions.

"Diphenhydramine": indications prescribed in the instructions

If you read the annotation, you will find out that the drug has antihistamine, sedative and hypnotic effects. The last two qualities are often considered side effects from use. But doctors use them when prescribing the drug for certain pathologies. The instructions specify the following indications for use of the drug:

• allergies of various origins (hay fever, urticaria, allergic dermatoses, Quincke's edema);
• serum sickness;
• stomach and intestinal ulcers;
• vomiting caused by seasickness or toxicosis of pregnancy;
• Meniere's syndrome;
• radiation sickness;
• parkinsonism.

Scope of application: what does the medicine help with?

You already know in what situations the instructions recommend using the medicine "Diphenhydramine". What else can this medication help with? If you delve deeper into the medical use of the drug, you will find out that the range of its uses is quite wide.

"Diphenhydramine" is used in allergology to eliminate acute reactions that require urgent intervention. The drug can relieve different types of allergies: from a common runny nose and skin rash to serious swelling, bronchospasm or laryngospasm. The medication acts on the central nervous system. It is used to eliminate spasm of smooth muscles. The drug is prescribed for increased capillary permeability. Due to its sedative effect, Diphenhydramine is used for increased excitability. The medication is used to treat bronchial asthma and similar respiratory diseases. With its help, white fever can be easily eliminated. Very often, the drug "Diphenhydramine" is combined with other medications. Let's take a closer look at the use of antihistamines.

Allergy treatment

If you ask someone: “What does Diphenhydramine help with?”, the most likely answer will be: allergies. Indeed, this medication was originally valued for its antihistamine properties. The drug can eliminate even a severe allergic reaction. It is used for intolerance to certain foods (food allergies). Diphenhydramine is prescribed when an unexpected reaction to a drug occurs. Often it is so strong that a person changes in a matter of seconds: swelling appears, the face turns red, breathing and speech become difficult. The use of Diphenhydramine in such situations is justified and advisable. The medicine blocks histamine receptors, reduces the severity of the inflammatory process, and eliminates swelling. The maximum effect occurs within a few minutes and lasts for 12 hours.

The dosage of the medication is always determined individually. For adult patients, a single dose ranges from 1 to 5 milliliters of solution. For chronic allergies, it is recommended to use minimal doses. An acute reaction requires administration of the maximum amount of the drug. The tablets are prescribed by doctors in a volume of ½-1 pill. The frequency of use is 1-3 times a day. The duration of treatment should not exceed two weeks.

White fever

Very often in medicine the combination of “Analgin” and “Diphenhydramine” is used. For fever, this remedy is considered the most effective. Also, an antispasmodic is necessarily added to this composition. Despite the fact that Diphenhydramine has a smooth muscle relaxing effect, this is not enough. The action is due to its components:

• "Analgin" reduces body temperature and has an analgesic effect;
• "Diphenhydramine" eliminates the possibility of allergies, soothes and relaxes;
• “No-Spa” or any other antispasmodic affects the muscles and blood vessels, normalizing their function and relieving tension.

The drugs "Analgin" and "Diphenhydramine" for fever are necessary when other antipyretics are powerless. In such situations, a person’s extremities often become cold: arms and legs. Less commonly, chills may occur. The thermometer level crosses the border at 38-39 degrees, and continues to rise, despite the use of antipyretic drugs. How to properly give a Diphenhydramine injection with Analgin? The dosage of each medication is determined by the age of the patient.

• For adults, no more than 100 milligrams of Diphenhydramine and one gram of Analgin are administered per injection.
• The drugs “Analgin” and “Diphenhydramine” are prescribed to the child according to age. The daily amount of drugs is calculated using the formula 10 mg of Analgin + 0.41 mg of Diphenhydramine for each kilogram of body weight.

Please note the restrictions

Like any medicine, Diphenhydramine has its contraindications. It is not used if you are allergic to the main active ingredient. It is prohibited to use the medicine for epilepsy, prostate adenoma, and closed-angle glaucoma. If there is a suspicion of bladder neck stenosis or digestive tract, then it is necessary to conduct an examination before using the medication. When prescribing a drug, the doctor can give individual recommendations, in connection with which it will be necessary to replace the drug with an alternative one. Do not use Diphenhydramine on your own. Due to the fact that the drug is not sold without a prescription, you most likely will not be able to do this. Those outlets, online pharmacies and underground databases that offer this medicine for free sale - they are all engaged in illegal activities and can sell you a counterfeit.

Diphenhydramine and alcohol

Quite often you can hear about the use of this medication with alcoholic beverages. In this way, the consumer tries to achieve hallucinations, relax, and enter euphoria. It’s worth saying right away that all this is not only dangerous to health. Such experiments can be fatal. That is why, recently, Diphenhydramine has become sold exclusively as prescribed by a doctor.

If you use Diphenhydramine for allergies, then during treatment you need to give up any alcohol, even beer. The combination of chemicals in one body entails negative consequences for the digestive tract. Irritation of the gastric walls can result in gastritis or ulcers. The drug, together with ethanol, has a detrimental effect on the liver and intestinal function. With this combination, a person experiences lethargy, drowsiness, decreased blood pressure, shortness of breath and tachycardia. There is a high probability of intoxication and the use of four tablets of the drug leads to death!

"Diphenhydramine" with other drugs

As has already become known, the drug is often used with Analgin. It is also combined with other antipyretics: Paracetamol, Ibuprofen. But this combination is used less often. “Diphenhydramine” combines well with antispasmodics: “No-Shpoy”, “Drotaverine”, “Papaverine” and so on. It is permissible to use an antihistamine with sorbents, antiviral, anti-inflammatory compounds and antibiotics. The following types of combinations are considered separately.

1. The drug enhances the effectiveness of medications that affect the functioning of the central nervous system.
2. Agents that inhibit monoamine oxidase can enhance the clouding and sedative effect of the drug.
3. The use of psychostimulants causes an antagonistic interaction.
4. "Diphenhydramine" reduces the effect of drugs used in case of poisoning to induce vomiting.

If you use any cardiac tranquilizers or narcotic medications, then the possibility of combination with Diphenhydramine should be considered individually.

Side effects

The medicine "Diphenhydramine", no matter what you take it for, can cause adverse reactions. If these occur, you must stop using the medication and immediately consult a doctor. Among the negative effects of the medication are the following:

• drowsiness, dizziness, weakness, clouding of consciousness, fainting;
• tremor, euphoria, convulsions, insomnia, mental agitation;
• increased viscosity of bronchial mucus, respiratory distress, dry mouth;
• thrombocytopenia, hemolytic anemia;
• decreased blood pressure, decreased urination;
• skin itching, rash, swelling.

Summarize

From the article you were able to learn about the features of using the drug "Diphenhydramine". As it turns out, it is often used in medicine. But to prescribe, the patient must have certain indications. Do not self-medicate. Contact doctors for qualified assistance. Best wishes!

Everyone knows that for insomnia and anxiety, Diphenhydramine is used for sleep. In addition, this drug has antihistamine, analgesic and antispasmodic effects. In order for a drug to have the desired effect on the human body, you need to know its indications, as well as possible side effects.

Description of the drug

Diphenhydramine is produced in the form of tablets in blisters of 20, 30 or 50 mg, ampoules for intramuscular or intravenous injection. In addition, the following dosage forms are commercially available:

• soluble powder;
• liquid capsules;
• candles;
• stripes;
• gels.

The active ingredient is diphenhydramine.

What are the indications for use?

The drug in various dosage forms is prescribed for the treatment of the following pathologies:

• insomnia;
• allergic conjunctivitis, rhinitis;
• the body's reaction to plant flowering;
• serum sickness;
• acute iridocyclitis;
• hives;
• itchy dermatoses;
• hay fever;
• complications of an allergic nature during the treatment of radiation sickness, blood transfusions and replacement fluids;
• Quincke's edema;
• treatment of abnormal movements, including Parkinson's disease, Meniere's syndrome;
• in complex therapy of gastric ulcers, anaphylactic shock, bronchial asthma, gastritis;
• skin and soft tissue injuries;
• motion sickness and vomiting in transport, with air and sea sickness.

The dosage and treatment regimen are prescribed by the doctor after examining and examining the patient.

Opinion of a somnologist: “Diphenhydramine (Diphenhydramine) is a drug from the group of H1 blockers - first generation histamine receptors, created in the 40s in the USA and at that time was the first medicine for the treatment of allergies.
In addition to the anti-edematous, analgesic, antiemetic effect, it has a pronounced sedative effect.

It depresses the central nervous system, causing dizziness, loss of coordination, and decreased concentration (which is especially bad for working active patients). The effect of the drug depends on the dose and duration of use; over time, an increase in dosage is required, which leads to side effects (for example, dry mucous membranes, blurred vision, gastrointestinal dysfunction).

Nowadays, Diphenhydramine is widely used in emergency situations, in hospital settings, or in combination with drugs to treat seriously ill patients.
Using Diphenhydramine at home alone to correct insomnia is not justified and is dangerous. Now there are other safer drugs for the treatment of insomnia.”

Somnologist.

Contraindications and special instructions

Along with its wide range of uses, Diphenhydramine has a number of contraindications that should not be neglected.

This drug should not be taken by persons who have been shown to be hypersensitive to any of the components of the drug while driving. vehicle, as well as in the presence of the following diseases:

• prostate hypertrophy;
• closed-type glaucoma;
• epilepsy;
• stenosis of gastric ulcer, bladder neck;
• children (prematurity and newborn period).

Therapy with Diphenhydramine should be carried out with caution in cases of pulmonary pathologies, increased intraocular pressure, in old age, with heart and vascular diseases, pulmonary pathologies, during pregnancy and lactation. The substance is not recommended for use by people whose occupation requires concentration or driving.

People who suffer from phenylketonuria need to know that instant capsules and chewable tablets containing Diphenhydramine often contain aspartame, a source of phenylalanine.

Side effect

Uncontrolled use medicinal product, its overdose or combination with other pharmaceutical products can provoke the development of adverse reactions.

The most commonly observed disorders are:

• from the digestive system: dry mouth, nausea, vomiting, stool disorders, loss of appetite, numbness of the mucous membrane;
• nervous system: drowsiness, neuritis, convulsions, fatigue, euphoria, impaired coordination of movements, weakness, headache;
• respiratory system disorder: congestion or dryness of the nasal passages, difficulty breathing, thickening of bronchial secretions;
• changes in heart activity and vascular condition, namely: palpitations, thrombocytopenia, hypotension, anemia, tachycardia;
• allergic reactions.

In addition, the patient may experience increased sweating or chills, photosensitivity.

In case of overdose, a pronounced depressed state or overexcitation, depression, dilated pupils, reddening of the face.

If an injection is necessary, doctors do not recommend the method of injecting under the skin.

Attention! In severe cases, children may develop confusion, seizures, and even death.

After taking medication to relieve side effects It is necessary to perform gastric lavage and monitor blood pressure.

Benefits of use

Reviews from people who have taken Diphenhydramine in various forms indicate that it can be very effective in developing infectious diseases, relieving swelling and redness in the mucous membranes and helping the patient to sleep.

Diphenhydramine in combination with other drugs reduces high fever well and enhances the effect of the latter. This lytic mixture has an analgesic and hypnotic effect. If allergic reactions occur on the skin, it is better to use ointments, aerosols or lotions that contain diphenhydramine. Such medications have a local effect on the problem area, relieve itching and discomfort. In addition, local application avoids systemic effects such as drowsiness and does not affect the gastric mucosa. For insect bites, you can use a solution from an ampoule, which you need to moisten a cotton swab and apply to the affected area.

Other advantages:

• cheapness;
• fast action;
• decreased blood pressure;
• calming effect;
• maintaining the effect throughout the day.

Negative points

Despite a number of positive qualities, the product has disadvantages that make you think about the advisability of its use.

Minuses:

• prescription only;
• new generation analogues are more accessible and cause fewer adverse reactions;
• in the form of injections it is more effective than in tablets;
• addictive;
• toxic, may cause hallucinations;
• must be taken strictly according to instructions;
• lethargy, inability to control emotions;
• causes headaches and poor health the next morning.

Can it be given to children?

It is not recommended to take tablets for the treatment of colds and coughs. The child may choke. In case of relieving allergic manifestations, it is better to use rectal suppositories after performing an enema. For insomnia or sleep disturbances, children are given milder sedatives that do not cause complications. Intramuscular Diphenhydramine is administered to children only in mixtures with other pharmaceutical products in order to reduce high fever under the supervision of a physician.

During pregnancy and lactation

This drug can be used during pregnancy only as prescribed by a specialist. If the pathology can have serious consequences and negatively affect the fetus, the woman may be allowed to take this substance, taking into account the duration of pregnancy. In this case, the treatment of symptoms of urticaria, conjunctivitis or itchy dermatosis is carried out by taking tablets once or twice.

Important! Diphenhydramine is contraindicated in the first and second trimester.

The drug is not prescribed during lactation due to the risk of complications for the child.

How does it affect the elderly?

People over 65 years of age are not recommended to take the drug due to the fact that they may haveanticholinergic effect, which has the following manifestations:

• violation of accommodation;
• increased heart rate;
• dizziness;
• urinary retention
• constipation, intestinal obstruction;
• memory loss.

Interaction with alcohol

Preparations containing dimerdol enhance the effects of alcohol and cause irreparable harm to the body. The liver and kidneys are primarily affected. Taking a small dose of alcohol with a tablet of the drug, the alcoholic becomes intoxicated. Outwardly, this manifests itself in increased gesticulation, agitation and aggression. Then comes a deep, dreamless sleep. Terrible hallucinations often occur; they are accompanied by hand tremors, blurred vision, and tachycardia. Repeated combination of Diphenhydramine with alcoholic drinks leads to apathy, addiction, personality destruction and death.

"Analgin" is an antipyretic and analgesic agent, a pyrazolone derivative. "Diphenhydramine" has an antihistamine, sedative, anti-inflammatory effect. Injections of "Analgin" with "Diphenhydramine" are most often used for infectious pathologies and inflammatory processes. The high fever usually subsides within fifteen minutes after the injection. These can also be prescribed for pain after surgery, injuries, renal and hepatic colic, and myalgia.

Analgin injection with Diphenhydramine can be prescribed for neuralgia, headaches, and toothaches.

The therapeutic effect of the drugs lasts five to six hours, after which the active substances are excreted from the body in the urine. Before "Analgin" with "Diphenhydramine", you need. For children over 14 years of age, you must take one ampoule of each medicine. The drugs are drawn into one syringe. The dosage for children is calculated based on body weight and severity of the condition.

How to give an injection of "Analgin" with "Diphenhydramine"

The dosage of Analgin with Diphenhydramine for injection requires caution. Adults should be administered 1-2 milliliters of a 25% or 50% solution. The maximum permissible dose is 2 g per day. children are given at the rate of 0.1-0.2 milliliters of a 50% solution or 0.2-0.4 milliliters of a 25% solution per ten kilograms of body weight. Injections of "Analgin" with "Diphenhydramine" are given no more often than once every six hours.

It is necessary to strictly observe the rules of antisepsis and asepsis, since with intramuscular injection there is a risk of an abscess with suppuration of the muscle fibers and subcutaneous layer. Before opening, the ampoules should be warmed to the patient’s body temperature, then they should be treated with an alcohol solution. First, “Analgin” is drawn into the syringe, and then “Diphenhydramine”. An injection of Analgin with Diphenhydramine is placed intramuscularly in the upper quadrant of the buttock. Introduce the solution slowly and carefully.

If the temperature does not decrease after the injection, you should urgently call a doctor.

To avoid dehydration, the patient should drink half a liter of water after the injection. Injections of the drugs “Analgina” and “Diphenhydramine” are contraindicated in case of severe pathologies of the kidneys, liver, diabetes mellitus, bronchial asthma, and blood diseases. They are not given to children under one year of age, pregnant or lactating women. If possible, it is recommended that high temperature call a doctor. Home injections should only be used as a last resort.